In Silico Docking Analysis of Selected Anti-Oxidant Compounds Against VEGF Protein
Keywords:VEGF-A, iGEMDOCK, Antioxidants, In Silico Analysis, Hesperidin, Ascorbic Acid, Quercetin, Gallic Acid, Anti-Angiogenic
Vascular Endothelial Growth Factor (VEGF) is a key regulator of vasculogenesis and angiogenesis. Although,
expression of VEGF is necessary for body functioning but its overexpression supports oncogenesis. Therefore, it
has become a major target for the development of cancer therapeutics. Various anti-VEGF compounds have
been explored for anti-angiogenic properties and are presently under clinical trials. The present study is focused
on in silico analysis of various known antioxidants against VEGF-A, using iGEMDOCK software. Hesperidin
has shown minimum binding energy -121.04 kcal mol-1 amongst all antioxidants, followed by quercetin (-98.79
kcal mol-1), gallic acid (-77.49 kcal mol-1) and ascorbic acid (-68.42 kcal mol-1). Hesperidin, a known anti-
angiogenic compound, appeared to be the best inhibitor of VEGF-A, and may be further explored for
development of anticancer drug.
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