Retinoids Induced Cancer Stem Cell Differentiation and Apoptosis for Cancer Therapies

  • Xin Cao Project Leader of Targeted Drug Design and Validation, Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, Shanghai, 200032, China
Keywords: Retinoids, cancer stem cell, differentiation, apoptosis

Abstract

Retinoids show great potential in various kinds of cancer chemotherapy due to its ability to induce signals for cell differentiation or death, as well as inhibit cancer stem cell proliferation. This paper summarized the recent progress of retinoids induced cancer stem cell differentiation and apoptosis in cancer therapy field, with the highlighted novel retinoid named WYC-209 in our lab, which could inhibit the tumor stem cell and malignant melanoma tumors with high efficacy and little toxicity.

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Published
2019-04-01
Section
Research Article