Platelet dysfunction in injured patients

  • Noelle Saillant Division of Traumatology, Department of Surgery Critical Care and Acute Care Surgery, University of Pennsylvania, University of Pennsylvania, 3400 Spruce Street, 5 Maloney, Philadelphia, Pennsylvania, USA
  • Carrie Sims Division of Traumatology, Department of Surgery Critical Care and Acute Care Surgery, University of Pennsylvania, University of Pennsylvania, 3400 Spruce Street, 5 Maloney, Philadelphia, Pennsylvania, USA
Keywords: Trauma, Hemostasis, Platelet activation, Platelet function, Platelet storage lesion, Platelet mitochondrial dysfunction, Coated platelets, Resuscitation, Coagulopathy

Abstract

A renewed understanding of Trauma Induced Coagulopathy (TIC) has implicated platelets as a crucial mediator and
potential therapeutic target in hemostasis. While the importance of abnormal coagulation tests is well described in
trauma, there is a paucity of data regarding the role of platelets in coagulopathy. New coagulation models, namely
the cell-based-model of hemostasis, have refocused attention toward the platelet and endothelium as key regulators of
clot formation. Although platelet dysfunction has been associated with worse outcomes in trauma, the mechanisms
which platelet dysfunction contributes to coagulopathy are poorly understood. The goal of this review article is to
outline recent advances in understanding hemostasis and the ensuing cellular dysfunction that contributes to the
exsanguination of a critically injured patient.

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Published
2014-12-19
Section
Review