Dexamethasone Induced Modulation of Reproduction: Investigating Role of Dexras1 Monomeric G Protein
Many factors like hormonal, anatomical, genetic, and environmental etc effect reproduction. Stressful conditions like emotional-stress, altered level of hormones etc can cause alterations in release of reproductive hormones thus ultimately effecting reproduction. In our study, we have focused to know the modulation of reproduction induced by Dexamethasone(DEX)(a synthetic glucocorticoid), which mimics as a stress conditionin female miceand investigated the role of Dexras1 in reproductionunder the influence of Dexamethasone. Glucocorticoid are known toinfluence the release of GnRH hormone which in turn regulate the release of reproductive hormones(LH, FSH). Dexamethasone is reported to upregulates Dexras1 expression. Sowe have investigatedthe modulation of reproduction by alteration in the release of reproductive hormones LH and FSH under DEX dosage in female mice. We observed that the level of hormones LH and FSH altered, in the presence of Dexamethasone doses (0.1 and 0.5mg/kg mice). LH level is decreased while the level of FSH increasedwith DEX dose. So the present study reveals the role of Dexamethasone in modulation of reproduction. It has beenreported earlier that Dexras1 is upregulated by Dexamethasone so we couldsuggest that Dexras1 might involvein modulation of reproduction and could become a very important therapeutic target in reproduction signaling processes.
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